Thermophilic Adaptation of Protein Complexes Inferred from Proteomic Homology Modeling

Generalized Local Homology Modules of Complexes

The theory of local homology modules was initiated by Matlis in 1974. It is a dual version of the theory of local cohomology modules. Mohammadi and Divaani-Aazar (2012) studied the connection between local homology and Gorenstein flat modules by using Gorenstein flat resolutions. In this paper, we introduce generalized local homology modules for complexes and we give several ways for computing ...

Protein rigidity and thermophilic adaptation.

We probe the hypothesis of corresponding states, according to which homologues from mesophilic and thermophilic organisms are in corresponding states of similar rigidity and flexibility at their respective optimal temperatures. For this, the local distribution of flexible and rigid regions in 19 pairs of homologous proteins from meso- and thermophilic organisms is analyzed and related to activi...

Probabilistic protein homology modeling

Homology-based modeling of 3D structures of protein-protein complexes using alignments of modified sequence profiles.

Customary practice in predicting 3D structures of protein-protein complexes is employment of various docking methods when the structures of separate monomers are known a priori. The alternative approach, i.e. the template-based prediction with pure sequence information as a starting point, is still considered as being inferior mostly due to presumption that the pool of available structures of p...

Proteomic analysis of lipid-protein complexes